1. 细胞的基础信息

2. 细胞常见的研究有哪些？

a) 研究膀胱的生物学特性

b) 药物筛选及膀胱癌治疗的研发

c) 有关该膀胱癌耐药机制的研究

d) 建立细胞模型

3. 细胞相关的文献有哪些？

[1] 薛雨晴,王子瑞,赵奇.CDK7抑制剂THZ1对膀胱癌5637细胞系增殖和凋亡的影响[J].牡丹江医学院学报,2024,45(01):11-15.

（目的：探究细胞周期依赖性激酶7(cyclin-dependent kinase 7,CDK7)抑制剂THZ1对膀胱癌5637细胞系增殖和凋亡的影响。方法：采用CCK8实验检测细胞的药物毒性情况，筛选有效药物浓度。采用平板克隆实验评估其在体外的抗肿瘤活性，研究其在一定剂量浓度内对肿瘤细胞的增殖能力的抑制作用。采用划痕实验测定药物对肿瘤细胞迁移能力的影响。采用Western blot实验检测凋亡蛋白的表达水平。结果：CCK8结果显示CDK7抑制剂THZ1对膀胱癌5637细胞系增殖能力具有抑制作用(P<0.05)。平板克隆实验显示CDK7抑制剂THZ1对膀胱癌5637细胞系的增殖能力有抑制作用(P均<0.05)。划痕实验显示CDK7抑制剂THZ1对膀胱癌5637细胞系的迁移能力有抑制作用(P均<0.05)。Western blot实验显示CDK7抑制剂THZ1对膀胱癌5637细胞系的蛋白表达水平有抑制作用(P均<0.05)。结论：CDK7抑制剂THZ1对膀胱癌5637细胞系增殖有抑制作用、促进凋亡作用，该项研究结果提示CDK7抑制剂THZ1对膀胱癌有治疗效果。关键词：膀胱癌;膀胱癌5637细胞;CDK7;THZ1）

[2] Aminzadeh Z, Ziamajidi N, Abbasalipourkabir R, Daei S, Helbi S, Moridnia A. Antitumor Activities of Aqueous Cinnamon Extract on 5637 Cell Line of Bladder Cancer through Glycolytic Pathway. Int J Inflam. 2022;2022:3855368.

（Background: Pharmacotherapy with medicinal plants is a promising approach to treat cancer. Cinnamon is a medicinal plant whose properties have been proven in various fields of medical sciences. Among its biological activities, its antioxidant and antiviral effects can be mentioned. In this study, the antitumor effects of Cinnamon with a focus on glucose metabolism in bladder cancer carcinoma cell-line 5637 were investigated. Methods: Aqueous extract of Cinnamon was prepared from Cinnamon bark. Bladder cancer 5637cell line were treated with different concentrations of aqueous extract of Cinnamon. MTT was used to evaluate cell viability at 24, 48, and 72 h. The concentration of 1.25, 2.50, and 5 mg/ml was used. Apoptosis was assessed with Hochest33258 staining. For evaluating of aqueous extract of Cinnamon effect on glycolysis, the gene expression of epidermal growth factor receptor 2 (ErbB2), heat shock protein transcription factor1 (HSF1), and lactate dehydrogenase A (LDHA), as well as protein levels of HSF1 and LDHA, LDH activity, glucose consumption, and lactate production, were measured. Results: Aqueous extract of Cinnamon significantly decreased ErbB2, HSF1, and LDHA gene expression and also decreased the protein level of HSF1 and LDHA, LDH activity, glucose consumption, and lactate production dose-dependently (p < 0.05). Conclusion: Our finding showed that the aqueous extract of Cinnamon can inhibit proliferation in 5637 cells by inhibition of glycolysis and induction of apoptosis.）